Free Ebook Stearoyl-CoA Desaturase Genes in Lipid Metabolism
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Published on: 2013-08-15
Released on: 2013-08-15
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Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. Brown and beige fat: development function and therapeutic ... In rodents a number of tissues and cell types have been found to secrete factors that regulate brown and beige adipose activity through systemic autocrine and ... Lipid Metabolism - The Medical Biochemistry Page The lipid synthesis and metabolism page provides a detailed description of the structure synthesis and metabolism of fatty acids triglycerides and phospholipids. Lipid - Wikipedia Glycerophospholipids usually referred to as phospholipids are ubiquitous in nature and are key components of the lipid bilayer of cells as well as being involved ... Stearoyl-CoA desaturase-1 - Wikipedia Stearoyl-CoA desaturase (-9-desaturase) is a protein that in humans is encoded by the SCD gene. Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. Understanding Dietary Fats and Oils: - Doctor HOME. Below is a previous version of the book in web format. Please forgive the formatting rendering errors. Understanding Dietary Fats and Oils /Blog The Fat Emperor See the full 2015 interview where Dr. Kraft details extensively how hyperinsulinemia/diabetes is the primary driver of atherosclerosis and heart attacks in the world ... Specialized hepatocyte-like cells regulate Drosophila ... In mammals specialized cells of the adipose tissue and liver are critical for coordinating fat metabolism. This physiological axis regulates a complex set of lipid ... Primary Prevention of Cardiovascular Disease with a ... Original Article. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. Ramn Estruch M.D. Ph.D. Emilio Ros M.D. Ph.D. Jordi Salas-Salvad ... Minerals: Critical Micronutrients Minerals constitute one of two major classes of biologically critical micronutrients required for normal health and development of humans. The other class are the ... CHRONOLOGICAL HISTORY OF - Cyberlipid Important dates in the history of lipids ... 1669. The alchemist Brandt Hennig is credited to have prepared phosphorus (phosphoro mirabile) the first element ...
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